The error atheists make is thinking that Aristotle meant the Prime Mover was like the person who pushes the first domino, setting off a series of events. The person in this analogy had a cause, her parents created her, therefore God must have a creator as well. God, according to Aristotle and St. Thomas, did not set the Universe in motion by giving it a push; God is the teleology (the purpose served by change rather than by postulated causes) of the causal Universe.
The question atheists need to ask themselves is why would God tell us what we can figure out ourselves? Indeed the Bible does not contain a scientific explanation of our existence, but rather a transcendental explanation.
Therein lies the great fallacy of atheism. You tell me the Universe is not guided by reason because it can be explained by reason. You say our existence is merely part of a system which follows logic, and therefore the system has no logic.
Why does science work? Ask that to an atheist, and they will say it just does. Duh. Of course it does. It makes perfect sense. It is self correcting, peer reviewed, and when experiments produce consistent results this implies something factual about the world. To an atheist, if science can’t explain it then it doesn’t exist. To this claim, I say “prove it.”